2-aminobicyclo[2,2,1]heptane-2-carboxylic acid

2-aminobicyclo[2,2,1]heptane-2-carboxylic acid is a **synthetic amino acid derivative** most commonly used as a **selective inhibitor of the large neutral amino acid transporter 1 (LAT1, also called "System L")**[1][2][5]. It competes for the transporter, blocking the cellular uptake of L-type amino acids such as L-leucine and L-dopa, making it a **tool compound** in transporter research and preclinical studies. BCH has shown utility in cancer research by suppressing LAT1-mediated amino acid uptake, leading to **antiproliferative and pro-apoptotic effects** in cancer cells[2][5]. It can also act as an **activator of the mitochondrial enzyme glutamate dehydrogenase (GDH)** in some research contexts[7]. Primary use is as a research tool compound, not a pharmaceutical.

Other names

2-amino-2-norbornanecarboxylic acid2-aminonorbornane-2-carboxylic acid2-Amino-2-carboxy-bicyclo-2,2,1-heptane3-amino-3-bicyclo[2.2.1]heptanecarboxylic acid3-aminobicyclo[2.2.1]heptane-3-carboxylic acid